Histopathology Articles

AmpathChat #53 - Molecular testing in colorectal carcinoma

Colorectal carcinomas arise from colorectal epithelium, which has undergone a series of molecular changes, referred to as the adenoma-carcinoma progression sequence.4 With increasing genetic mutations, progression from normal epithelium to adenomas with dysplasia occurs. Eventually, adenomas that show high-grade dysplasia give rise to invasive colorectal carcinomas.

AmpathChat #52 - Breast Cancer

All individuals with a positive family history of breast or ovarian cancer are not equally at risk. The likelihood that BRCA testing will be informative should be assessed prior to testing.

AmpathChat #42 - Frozen Section - An Invaluable Tool for Intra-operative Surgical Consultation

The frozen section technique has evolved and has improved immensely from 1818, when Dutch anatomist Pieter de Reimer utilised cold brine (salt water) to harden tissues, until 1895, when Thomas Cullen, MD, published the first written frozen section technique from Johns Hopkins [1].

AmpathChat #16 - Cervical Cancer Screening - Role of HPV DNA Based Screening and Cytology

Genital infection with human papillomavirus (HPV) is the most common sexually transmitted infection today, and persistent infection with high-risk genotypes is the cause of cervical cancer. Over 40 HPV genotypes infect mucosal surfaces, including the anogenital epithelium (e.g. cervix, vagina, vulva, rectum, urethra, penis and anus).